1. Local Integrated Software Architecture.A personal computer introduced by Apple Computer, Inc. in 1983.The LISA was a predecessor of the Macintosh and was the first personal computer on the market with a {graphical user interface}.It was origionally named after Steve Jobs' s daughter.The acronym was applied later.[Spec?]2. A system for statistical data analysis, similar to S.FTP MIT .3. Large Installation Systems Administration.(2001-10-16)