1. Local IntegrATed Software Architecture. A personal computer introduced by Apple Computer, Inc. in 1983. The LISA was a predecessor of the Macintosh and was the first personal computer on the market with a {graphical user interface}. It was origionally named after Steve Jobs' s daughter. The acronym was applied lATer. [Spec?] 2. A system for stATistical dATa analysis, similar to S. FTP MIT . 3. Large InstallATion Systems AdministrATion. (2001-10-16)