1. Local Integrated Software Architecture. A personal computer introduced by Apple Computer, Inc. in 1983. The LISA was a predecessor of the Macintosh and was the first personal computer on the market with a {graphical user interface}. It was origionally named after Steve Jobs' s daughter. The acronym was applied later. [Spec?] 2. A system for stATIStical data analysis, similar to S. FTP MIT . 3. Large Installation Systems Administration. (2001-10-16)