1. Local INTegrated Software Architecture. A personal computer iNTroduced by Apple Computer, Inc. in 1983. The LISA was a predecessor of the MaciNTosh and was the first personal computer on the market with a {graphical user iNTerface}. It was origionally named after Steve Jobs' s daughter. The acronym was applied later. [Spec?] 2. A system for statistical data analysis, similar to S. FTP MIT . 3. NT> Large Installation Systems Administration. (2001-10-16)