1. Local Integrated Software Architecture. A perSonal computer introduced by Apple Computer, Inc. in 1983. The LISA waS a predeceSSor of the MacintoSh and waS the firSt perSonal computer on the market with a {graphical uSer interface}. It waS origionally named after Steve JobS' S daughter. The acronym waS applied later. [Spec?] 2. A SyStem for StatiStical data analySiS, Similar to S. FTP MIT . 3. Large InStallation SyStemS AdminiStration. (2001-10-16)