1. Local Integrated software Architecture. A personal computer introduced by Apple Computer, Inc. in 1983. The LIsA was a predecessor of the Macintosh and was the first personal computer on the market with a {graphical user interface}. It was origionally named after steve Jobs' s daughter. The acronym was applied later. [spec?] 2. A system for statistical data analysis, similar to s. FTP MIT . 3. Large Installation systems Administration. (2001-10-16)